2026
199) A Safe Approach to meta-Fluorinated Pyridines
O. Rushchak, V. Sham, B. Dansberg, A. Kysil, T. Yegorova, P. K. Mykhailiuk*
Angew. Chem. Int. Ed. 2026, in press
198) Smallest Bicycles in Medicinal Chemistry: Where Are We Now?
V. Kubyshkin,* P. K. Mykhailiuk*
Chem. Rev. 2026, 126, 3829–3882
197) O-Vinylhydroxylamines for De Novo Pyrrole Synthesis
C. Randolph, O. Buravov, Z. Grimm, P. K. Mykhailiuk,* L. Kürti*
J. Am. Chem. Soc. 2026, 148, 21252–21257
196) Mechanistically Guided Functionalization of α,α-Disubstituted Alkenyl Amides Enabled by a Conformationally Flexible Directing Auxiliary
A. V. R. D. Lisboa, P. Yongpanich, S. Li, R. Hariharan, Y. Cao, Y. Gao, J. A. Gurak, P. K. Mykhailiuk, D. G. Blackmond,* P. Liu,* K. M. Engle*
J. Am. Chem. Soc. 2026, 148, 8936–8945
195) A C1-Homologative Trifluoromethylation: Light-Driven Decarboxylative Trifluoroethylation of Carboxylic Acids
F. Belnome, A. Pulcinella, S. Bonciolini, M. Lepori, O. P. Datsenko, Z. He, M. Gasparetto, P. K. Mykhailiuk, B. de Bruin,* T. Noël*
J. Am. Chem. Soc. 2026, 148, 7645–7654
194) Asymmetric C–H Functionalization of Bicyclo[2.1.1]hexanes and Their 2-Oxa- and 2-Aza Derivatives via Rhodium Carbene Intermediates
Z. Chen, D. Ly, Y. Kanda, V. V. Levterov, Y. Panasiuk, P. K. Mykhailiuk, D. G. Musaev,* H. M. L. Davies*
J. Am. Chem. Soc. 2026, 148, 2709–2718
![Asymmetric C–H Functionalization of Bicyclo[2.1.1]hexanes and Their 2-Oxa- and 2-Aza Derivatives via Rhodium Carbene Intermediates](https://mykhailiukchem.org/wp-content/uploads/2026/06/194.png)
193) Ring-Expansion of Ketones with [1.1.1]Propellane
G. A. Kadam, S. Midya, V. Levchenko, V. Sham, P. K. Mykhailiuk,* D. P. Hari*
J. Am. Chem. Soc. 2026, 148, 388–399
![Ring-Expansion of Ketones with [1.1.1]Propellane](https://mykhailiukchem.org/wp-content/uploads/2026/06/193.png)
192) Alkyl sulfonyl fluorides as ambiphiles in the stereoselective palladium(II)-catalysed cyclopropanation of unactivated alkenes
Y. Cao, W. Rodphon, T. M. Alturaifi, A. V. R. D. Lisboa, Z. Ren, J. J. C. Struijs, H.-Q. Ni, T. Savchuk, R. P. Loach, S. Yang, I. J. McAlpine, D. G. Blackmond, P. K. Mykhailiuk,* P. Liu,* K. B. Sharpless,* K. M. Engle*
Nature Synth. 2026, 5, 281–289
191) Triply convergent Ni-electrocatalytic assembly of 1,1-diaryl cyclobutanes, azetidines and oxetanes
L. Massaro, P. Neigenfind, A. Feng, G. Kuehn, F. C. Attard, A. DeSanti, M. R. Collins, M. Bravo, R. K. Twumasi, D. Chen, P. N. Bolduc, M. Nicastri, M. A. Emmanuel, M. S. Oderinde, M. D. Palkowitz, X. Zheng, A. C. Hunter, K. C. Harper, C. C. Tyrol, P. K. Mykhailiuk, Y. Kawamata, P. S. Baran*
Nature Chem. 2026, 18, 324–336
190) Direct α-C−H Heteroarylation of Unprotected Primary Amines
G. D. Johnson, S. A. Corio, J. D. Grayson, J. D. Tibbetts, G. Ballantyne, Q. Cao, H. E. Askey, J. J. Bell-Tyrer, O. P. Datsenko, M. A. Graham, P. K. Mykhailiuk, J. S. Hirschi,* A. J. Cresswell*
ACS Catal. 2026, 16, 10290–10296
189) Replacement of the Piperidine Ring with Aza-Spirocycles Reduces Cardiotoxicity of the Local Anesthetic Drug Bupivacaine
A. A. Kirichok, Y. Vaiser, I. Shton, O. Tarasov, M. Sokolenko, D. Lesyk, L. Dmytrovska, K. Khrenova, A. Soloviev, S. Tishkin, P. Borysko, Y. Holota, N. Diyuk, V. Chigrinov, T. Yegorova, D. Granat, P. K. Mykhailiuk,* V. Kubyshkin,* I. Pishel*
J. Med. Chem. 2026, 69, 12291–12306
188) Fused and Spirocyclic Sulfones for Medicinal Chemistry via [3 + 2] Cycloaddition of Thiocarbonyl Ylide
T. V. Rudenko, O. O. Stepaniuk, V. M. Timoshenko, A. A. Tolmachev, S. V. Shishkina, P. Mykhailiuk*
Org. Lett. 2026, 28, 1494–1498
![Fused and Spirocyclic Sulfones for Medicinal Chemistry via [3 + 2] Cycloaddition of Thiocarbonyl Ylide](https://mykhailiukchem.org/wp-content/uploads/2026/06/188.png)
187) Bicyclo[1.1.1]pentane Ketones via Friedel–Crafts Acylation
K. Urbańska, F. Ritterling, B. Twamley, O. Cseh, V. Levchenko, V. Ripenko, P. K. Mykhailiuk,* M. O. Senge*
J. Org. Chem. 2026, 91, 87–103
![Bicyclo[1.1.1]pentane Ketones via Friedel–Crafts Acylation](https://mykhailiukchem.org/wp-content/uploads/2026/06/187.png)
186) Fluorinated B-phenylated scorpionates as tunable platforms for stabilizing thallium(I) and silver(I)–ethylene complexes
A. Noonikara-Poyil, V. Q. H. Phan, M. Vanga, A. Boretskyi, P. Mykhailiuk,* H. V. R. Dias*
Dalton Trans. 2026, 55, 152–164
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