ERC-project

Research funded by ERC-consolidator grant “BENOVELTY” (101000893)

In this project, we plan to develop novel saturated bioisosteres of benzenes:

ERC-topic

Publications on the ERC-project

6) Water-soluble Bioisosteres of the ortho-substituted Phenyl Ring
A. Denisenko, P. Garbuz, N. M. Voloshchuk, Y. Holota, P. K. Mykhailiuk*
ChemRxiv 2022 (10.26434/chemrxiv-2022-tln0p-v2)
Water-soluble Bioisosteres of the ortho-substituted Phenyl Ring

5) Rapid and scalable halosulfonylation of strain-release reagents
H. D. Pickford, V. Ripenko, R. E. McNamee, S. Holovchuk, A. L. Thompson, R. C. Smith, P. K. Mykhailiuk,* E. A. Anderson*
Angew. Chem. Int. Ed. 2022, 61, e202213508
Rapid and scalable halosulfonylation of strain-release reagents

4) A Practical and Scalable Approach to Fluoro-Substituted Bicyclo[1.1.1]pentanes
R. Bychek, P. K. Mykhailiuk*
Angew. Chem. Int. Ed. 2022, 61, e202205103
A Practical and Scalable Approach to Fluoro-Substituted Bicyclo[1.1.1]pentanes

3) Unexpected Isomerization of Oxetane-Carboxylic Acids
B. Chalyk, A. Grynyova, K. Filimonova, T. V. Rudenko, D. Dibchak, P. K. Mykhailiuk*
Org. Lett. 2022, 24, 4722-4728
Unexpected Isomerization of Oxetane-Carboxylic Acids

2) Oxa-spirocycles: synthesis, properties and applications
K. Fominova, T. Diachuk, D. Granat, T. Savchuk, V. Vilchynskyi, O. Svitlychnyi, V. Meliantsev, I. Kovalchuk, E. Litskan, V. V. Levterov, V. R. Badlo, R. I. Vaskevych, A. I. Vaskevych, A. V. Bolbut, V. V. Semeno, R. Iminov, K. Shvydenko, A. S. Kuznetsova, Y. V. Dmytriv, D. Vysochyn, V. Ripenko, A. A. Tolmachev, O. Pavlova, H. Kuznietsova, I. Pishel, P. Borysko, P. K. Mykhailiuk*
Chem. Sci. 2021, 12, 11294-11305
Oxa-spirocycles: synthesis, properties and applications

1) Large-Scale Synthesis and Modifications of Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid (BCP)
V. Ripenko, D. Vysochyn, I. Klymov, S. Zhersh, P. K. Mykhailiuk*
J. Org. Chem. 2021, 86, 14061-14068
Large-Scale Synthesis and Modifications of Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid (BCP)

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Developed by George Malets (malets12@gmail.com)