2018
118) Low Heat of Adsorption of Ethylene Achieved by Major Solid‐State Structural Rearrangement of a Discrete Copper(I) Complex
N. B. Jayaratna, M. G. Cowan, D. Parasar, H. H. Funke, J. Reibenspies, P. K. Mykhailiuk, O. Artamonov, R. D. Noble, H. V. R. Dias
Angew. Chem. Int. Ed. 2018, 57, 16442-16446
117) (Chlorosulfonyl)benzenesulfonyl Fluorides—Versatile Building Blocks for Combinatorial Chemistry: Design, Synthesis and Evaluation of a Covalent Inhibitor Library
K. A. Tolmachova, Y. S. Moroz, A. Konovets, M. O. Platonov, O. V. Vasylchenko, P. Borysko, S. Zozulya, A. Gryniukova, A. V. Bogolubsky, S. Pipko, P. K. Mykhailiuk, V. S. Brovarets, O. O. Grygorenko
ACS Comb.Sci. 2018, 20, 672-680
116) One-Pot Synthesis of 6-Aminopyrido[2,3-d]pyrimidin-7-ones
A. M. Zinchenko, L. V. Muzychka, O. V. Kucher, I. V. Sadkova, P. K. Mykhailiuk, O. B. Smolii
Eur. J. Org. Chem. 2018, 46, 6519-6523
![One-Pot Synthesis of 6-Aminopyrido[2,3-d]pyrimidin-7-ones](https://mykhailiukchem.org/wp-content/uploads/2021/12/116_mod.png)
115) Photochemical In-Flow Synthesis of 2,4-Methanopyrrolidines: Pyrrolidine Analogues with Improved Water Solubility and Reduced Lipophilicity
V. V. Levterov, O. Michurin, P. O. Borysko, S. Zozulya, I. V. Sadkova, A. A. Tolmachev, P. K. Mykhailiuk*
J. Org. Chem. 2018, 83, 14350-14361
114) Saturated heterocyclic aminosulfonyl fluorides ‐ novel scaffolds for protecting‐group free synthesis of sulfonamides
S. Zhersh, O. Blahun, I. Sadkova, A. Tolmachev, Y. Moroz, P. Mykhailiuk*
Chem. Eur. J. 2018, 24, 8343-8349
113) Synthesis of Bi‐ and Polyfunctional Isoxazoles from Amino Acid‐Derived Halogenoximes and Active Methylene Nitriles
B. Chalyk, K. Hrebeniuk, K. Gavrilenko, O. Shablykin, O. Yanshyna, D. Bash, P. Mykhailiuk, O. Liashuk, O. Grygorenko*
Eur. J. Org. Chem. 2018, 22, 2753-2761
112) [2+2]-Photocycloaddition of N-benzylmaleimide to alkenes as an approach to functional 3 azabicyclo[3.2.0]heptanes
Y. Skalenko, T. Druzhenko, A. Denisenko, M. Samoilenko, O. Datsenko, S. Trofymchuk, O. Grygorenko, A. Tolmachev, P. Mykhailiuk*
J. Org. Chem. 2018, 83 (12), 6275–6289
![[2+2]-Photocycloaddition of N-benzylmaleimide to alkenes as an approach to functional 3 azabicyclo[3.2.0]heptanes](http://mykhailiukchem.org/wp-content/uploads/2018/06/112.png)
111) Preparation of 5-fluoropyrazoles from pyrazoles and NFSI
V. Levchenko, Y. Dmytriv, A. Tymtsunik, K. Liubchak, A. Rudnichenko, A. Melnyk, S. Veselovych, Y. Borodulin, O. Otsalyuk, A. Tolmachev, P. Mykhailiuk*
J. Org. Chem. 2018, 83 (6), 3265–3274
110) Synthesis of functionalized difluorocyclopropanes: unique building blocks for drug discovery
R. Bychek, V. Levterov, I. Sadkova, A. Tolmachev, P. Mykhailiuk*
Chem. Eur. J. 2018, 24, 12291-12297 (HOT paper 
)
109) Synthesis of multifunctional spirocyclic azetidines, and their application in drug discovery
A. Kirichok, I. Shton, I. Pishel, S. Zozulya, P. Borysko, V. Kubyshkin, O. Zaporozhets, A. Tolmachev, P. Mykhailiuk*
Chem. Eur. J. 2018, 24, 5444-5449
108) Synthesis of CHF2-substituted 3-azabicyclo[3.1.0]hexanes by photochemical decomposition of CHF2-pyrazolines
Y. Zheng, X. Yu, S. Lv, P. K. Mykhailiuk, Q. Ma,a L. Hai,* Y. Wu*
RSC Adv. 2018, 8, 5114-5118
![Synthesis of CHF2-substituted 3-azabicyclo[3.1.0]hexanes by photochemical decomposition of CHF2-pyrazolines](http://mykhailiukchem.org/wp-content/uploads/2018/06/108.png)
107) Photochemical Synthesis of 2-Azabicyclo[3.2.0]heptanes: Advanced Building Blocks for Drug Discovery. Synthesis of 2,3-Ethanoproline
T. Druzhenko, Y. Skalenko, M. Samoilenko, A. Denisenko, S. Zozulya, P. O. Borysko, M. I. Sokolenko, A. Tarasov, P. K. Mykhailiuk*
J. Org. Chem. 2018, 83 (3), 1394–1401
![Photochemical Synthesis of 2-Azabicyclo[3.2.0]heptanes: Advanced Building Blocks for Drug Discovery. Synthesis of 2,3-Ethanoproline](http://mykhailiukchem.org/wp-content/uploads/2018/06/107.png)
2017
106) Photochemical synthesis of 3-azabicyclo[3.2.0]heptanes: advanced building blocks for drug discovery
A. Denisenko, T. Druzhenko, Y. Skalenko, M. Samoilenko, O. Grygorenko, S. Zozulya, P. K. Mykhailiuk*
J. Org. Chem. 2017, 82, 9627–9636
![Photochemical synthesis of 3-azabicyclo[3.2.0]heptanes: advanced building blocks for drug discovery](http://mykhailiukchem.org/wp-content/uploads/2017/09/image1-1024x309.png)
105) Synthesis of spirocyclic pyrrolidines: advanced building blocks for drug discovery
B. Chalyk, M. Butko, O. Yanshyna, K. Gavrilenko, T. Druzhenko, P. K. Mykhailiuk*
Chem. Eur. J. 2017, 23, 16782–16786
104) Selective 19F-labeling of functionalized carboxylic acids with difluoromethyl diazomethane (CF2HCHN2)
P. K. Mykhailiuk,* I. Kishko,V. Kubyshkin, N. Budisa, J. Cossy
Chem. Eur. J. 2017, 23, 13279–13283
103) Heptafluoroisopropyl diazomethane (i-C3F7CHN2): in situ generation and synthesis of pyrazoles
P. K. Mykhailiuk*
Org. Biomol. Chem. 2017, 15, 7296-7301
102) Synthesis of N-nitroso CHF2-pyrazolines, and transformation into CHF2-isoxazolines and pyrazoles
P. Lebed, J. Fenneteau, Y. Wu, J. Cossy, P. K. Mykhailiuk*
Eur. J. Org. Chem. 2017, 31, 4530–4542
101) Conformational Plasticity of the Cell-Penetrating Peptide SAP as Revealed by Solid-State 19F-NMR and Circular Dichroism
S. Afonin, V. Kubyshkin, P. K. Mykhailiuk, I. V. Komarov, A. S. Ulrich
J. Phys. Chem. B. 2017, 121, 6479–6491
100) A peptidyl-prolyl model study: How does the electronic effect influence the amide bond conformation?
P. K. Mykhailiuk,* V. Kubyshkin,* T. Bach, N. Budisa
J. Org. Chem. 2017, 82, 8831-8841
99) Difluoromethyl nitril oxide (CF2HCNO): overseen chemical reagent
A. Khutoryanskiy, B. Chalyk, P. Borysko, A. Kondratiuk, P. Mykhailiuk*
Eur. J. Org. Chem. 2017, 27, 3935-3940
98) 1-Substituted 2-Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery
A. Kirichok, I. Shton, M. Kliachyna, I. Pishel, P. K. Mykhailiuk*
Angew. Chem. Int. Ed. 2017, 56, 8865-8869
highlighted in SynFacts, OPRD, Organometallic Chem, ChemViews
![1-Substituted 2-Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery](http://mykhailiukchem.org/wp-content/uploads/2018/06/98.png)
97) Synthesis of 6-azaspiro[4.3]alkanes: innovative scaffolds for drug discovery
B. Chalyk, A. Isakov, M. Butko, K. Hrebeniuk, O. Kucher, K. Gavrilenko, T. Druzhenko, V. Yarmolchuk, S. Zozulya, P. Mykhailiuk*
Eur. J. Org. Chem. 2017, 31, 4530-4542
![Synthesis of 6-azaspiro[4.3]alkanes: innovative scaffolds for drug discovery](http://mykhailiukchem.org/wp-content/uploads/2018/06/97.png)
96) Synthesis of functionalized 4-fluoropyridazines
A. Feraldi-Xypolia, G. Fredj, G. Tran, T. Tsuchiya, J.-P. Vors, P. Mykhailiuk, D.-G. Pardo, J. Cossy
Asian J. Org. Chem. 2017, 6, 927-935
95) Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR
S. L. Grage. M.-A. Sani, O. Cheneval, S. T. Henriques, C. Schalck, R. Heinzmann, J. S. Mylne, P. K. Mykhailiuk, S. Afonin, I. V. Komarov, F. Separovic, D. J. Craik, A. S. Ulrich
Biophys. J. 2017, 112, 630-642
94) Synthesis of fluorinated oxazoles by oxidative cyclization of fluorinated enamides
O. S. Shishlyk, A. V. Shcherbatiuk, R. T. Iminov, A. V. Tverdokhlebov,* A. A. Tolmachev, P. K. Mykhailiuk,* A. V. Biitseva
J. Fluorine.Chem. 2017, 196, 88-97
93) Synthesis of CF2H-substituted pyrazolines by [3+2]-cycloaddition between CF2HCHN2 and electron-deficient alkenes
J. Li, X.-L. Yu, J. Cossy, S.-Y. Lv, H.-L. Zhang, F. Su, L. Hai, P. K. Mykhailiuk,* Y. Wu*
Eur. J. Org. Chem. 2017, 2, 266-270
92) Synthesis of 3-oxadiazolyl/triazolyl morpholines: novel scaffolds for drug discovery
A. D. Tereshchenko, J. S. Myronchuk, L. D. Leitchenko, A. Tolmachev, K. Liubchak,* P. Mykhailiuk*
Tetrahedron 2017, 73, 750-757
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