2013-2011

2013

54) Stereochemical effects on the aggregation and biological properties of the fibril-forming peptide [KIGAKI]3 in membranes
P. Wadhwani, J. Reichert, E. Strandberg, J. Burck, J. Misiewicz, S. Afonin, N. Heidenreich, S. Fanghanel, P. K. Mykhailiuk, I. V. Komarov, A. S. Ulrich
Phys.Chem.Chem.Phys 2013, 15, 8962-8971

53) Design, synthesis and application of a CF3-phenylalanine analogue as a label to study peptides by solid state 19F-NMR
A. N. Tkachenko, D. S. Radchenko, P. K. Mykhailiuk,* S. Afonin,* A. S. Ulrich, I. V. Komarov
Angew. Chem. Int. Ed. 2013, 125, 6632-6635

52) A Convenient Route to 1-Alkyl-5-trifluoromethyl-1,2,3-triazole-4-carboxylic Acids Employing a Diazo Transfer Reaction
R. T. Iminov, A. V. Mashkov, B. A. Chalyk, P. K. Mykhailiuk, A. V. Tverdokhlebov, A. A. Tolmachev, Y. M. Volovenko, O. V. Shishkin, S. V. Shishkina
Eur. J. Org. Chem. 2013, 14, 2891-2897

51) Incorporation of labile trans-4,5-difluoromethanoproline into a peptide as a stable label for 19F-NMR structure analysis
V. S. Kubyshkin, P. K. Mykhailiuk,* S. Afonin, S. L. Grage, I. V. Komarov, A. S. Ulrich*
J. Fluorine Chem. 2013, 152, 136-143

50) Synthesis and characterization of β-trifluoromethyl-substituted pyrrolidines
V. S. Yarmolchuk, O. V. Shishkin, V. S. Starova, O. A. Zaporozhets, O. Kravchuk, S. Zozulya, I. V. Komarov, P. K. Mykhailiuk*
Eur. J. Org. Chem. 2013, 15, 3086-3093

49) 1-Amino-4,4-difluorocyclohexanecarboxylic acid as a promising building block for drug discovery
P. K. Mykhailiuk,* V. Starova, V. Iurchenko, S. V. Shishkina, O. V. Shishkin, O. Zaporozhets
Tetrahedron 2013, 20, 4066-4075

48) Synthesis of 2- and 3-trifluoromethylmorpholines: useful building blocks for drug discovery
A. V. Shcherbatiuk, O. S. Shyshlyk, D. V. Yarmolyuk, O. V. Shishkin, S. V. Shishkina, V. S. Starova, O. Zaporozhets, S. Zozulya, R. Moriev, A. A. Tolmachev, P. K. Mykhailiuk*
Tetrahedron 2013, 19, 3796-3804

47) An easy synthesis of α-trifluoromethyl-amines from aldehydes or ketones using the Ruppert-Prakash reagent
D. S. Radchenko, O. M. Michurin, A. V. Chernykh, O. Lukin,* P. K. Mykhailiuk*
Tetrahedron Lett. 2013, 54, 1897-1898

46) Silver(I) and Copper(I) Adducts of a Tris(pyrazolyl)borate Decorated with Nine Trifluoromethyl Groups
N. B. Jayaratna, I. I. Gerus,* R. V. Mironets, P. K. Mykhailiuk,* M. Yousufuddin, H. V. R. Dias*
Inorg. Chem. 2013, 52, 1691-1693

45) Synthesis of Isomeric 6-Trifluoromethyl-3-azabicyclo[3.1.0]hexanes: Conformationally Restricted Analogues of 4-Trifluoromethylpiperidine
O. S. Artamonov, E. Y. Slobodyanyuk, O. V. Shishkin, I. V. Komarov, P. K. Mykhailiuk*
Synthesis 2013, 45, 225-230

44) A 19F NMR Label To Substitute Polar Amino Acids in Peptides: A CF3-Substituted Analogue of Serine and Threonine
A. N. Tkachenko, P. K. Mykhailiuk, S. Afonin, D. S. Radchenko, V. S. Kubyshkin, A. S. Ulrich, I. V. Komarov
Angew. Chem. Int. Ed. 2013, 52, 1486-1489

2012

43) Incorporation of novel cis- and trans-4,5-Difluoromethano-prolines into Polypeptides
V. S. Kubyshkin, P. K. Mykhailiuk,* S. Afonin,* A. S. Ulrich, I. V. Komarov*
Org.Lett. 2012, 14, 5254–5257

42) An Improved Synthesis of 2-, 3-, and 4-(Trifluoromethyl)cyclohexylamines
A. N. Alekseenko, D. Klukovsky, O. Lukin, P. K. Mykhailiuk,* O. V. Shishkin, Y. M. Pustovit
Synthesis 2012, 44, 2739-2742

41) A Facile Synthesis of Isomeric C-(2,2,2-Trifluoroethyl)anilines
S. Trofymchuk, A. V. Bezdudny, Y. M. Pustovit, O. Lukin, A. N. Boyko, A. Chekotylo, A. A. Tolmachev, P. K. Mykhailiuk*
Synthesis 2012, 44, 1974-1976

40) Easy Synthesis of Novel 4-Azolylpyridazin-3-ones
O. V. Geraschenko, P. V. Khodakovskiy, O. V. Shishkin, P. K. Mykhailiuk,* A. A. Tolmachev
Synthesis 2012, 44, 1263-1267

39) Regioselective Reactions of Ethyl (4,5-Dihydrofuran-3-yl)-2-oxoacetate and Ethyl 2-(3,4-Dihydro-2H-pyran-6-yl)-2-oxoacetate with 1-Unsubstituted Aminoazoles
O. O. Stepaniuk, V. O. Matvienko, I. S. Kondratov, O. V. Shishkin, D. M. Volochnyuk, P. K. Mykhailiuk, A. A. Tolmachev
Synthesis 2012, 44, 895-902

38) Exploiting addition of CF3TMS to functionalized N-benzylimines for the preparation of two novel x-trifluoromethyl x-amino acids
A. N. Tkachenko, D. S. Radchenko, P. K. Mykhailiuk,* O. V. Shishkin, A. A. Tolmachev, I. V. Komarov
Synthesis 2012, 44, 903-908

37) An Efficient and Safe Method for the Multigram Synthesis of trans-2-(Trifluoromethyl)cyclopropylamine
V. S. Yarmolchuk, A. V. Bezdudny, N. A. Tolmacheva, O. Lukin, A. N. Boyko, A. Chekotylo, A. A. Tolmachev, P. K. Mykhailiuk*
Synthesis 2012, 44, 1152-1154

36) Reported, but still unknown. A closer look into 3,4-bis- and 3,4,5-tris(trifluoromethyl)pyrazoles
I. I. Gerus,* R. X. Mironetz, I. S. Kondratov, A. V. Bezdudny, Y. V. Dmytriv, O. V. Shishkin, O. A. Zaporozhets, A. A. Tolmachev, P. K. Mykhailiuk*
J. Org. Chem. 2012, 77, 47-56

2011

35) Multigram synthesis of 1-(difluoromethyl)imidazoles and -benzimidazoles
V. Levterov, O. O. Grygorenko,* P. K. Mykhailiuk,* A. A. Tolmachev
Synthesis 2011, 8, 1243-1248

34) Exploiting morph-DAST mediated ring-expansion of substituted cyclic β-amino alcohols for the preparation of cyclic fluorinated amino acids. Synthesis of 5‑fluoromethylproline and 5‑fluoropipecolic acid
P. K. Mykhailiuk,* S. V. Shishkina, O. V. Shishkin, O. A. Zaporozhets, I. V. Komarov
Tetrahedron 2011, 67, 3091-3097

33) Facile synthesis of 2-(ethyloxoacetyl)azoles
O. V. Geraschenko, P. V. Khodakovskiy, O. V. Shishkin, P. K. Mykhailiuk,* O. A. Zaporozhets, A. A. Tolmachev
Synthesis 2011, 10, 1633-1637

32) Reaction of N-Ethoxycarbonyl 3-acetyl-1,4,5,6-tetrahydropyridine with 1,3-N,N-bis-nucleophiles: a facile access to novel pyrimidine derivatives
N. B. Maximov, P. K. Mykhailiuk,* A. I. Kisel, Z. V. Voitenko, A. A. Tolmachev
Synthesis 2011, 9, 1465-1471

31) An improved synthesis of monoprotected 5- and 6-amino-2-azanorbornanes
O. Dacenko, O. V. Manoilenko, O. O. Grygorenko, P. K. Mykhailiuk, D. M. Volochnyuk, O. V. Shishkin, A. A. Tolmachev
Synth. Commun. 2011, 41, 981-992

30) Synthesis of β-fluoro-β-proline
V. S. Yarmolchuk, P. K. Mykhailiuk,* I. V. Komarov
Tetrahedron Lett. 2011, 52, 1300-1302

29) 5-(S)-Trifluoromethyl pyrrolidone: a Promising Building Block for Fluoroorganic Chemistry. Practical Synthesis of γ‑(S)‑Trifluoromethyl GABA and α‑(S)‑Trifluoromethyl Pyrrolidine
A. V. Bezdudny, A. N. Alekseenko, P. K. Mykhailiuk,* O. V. Manoilenko, O. V. Shishkin, Y. M. Pustovit
Eur. J. Org. Chem. 2011, 9, 1782-1785

28) Trifluoromethyl-substituted cyclopropanes
O. O. Grygorenko,* O. S. Artamonov, I. V. Komarov, P. K. Mykhailiuk*
Tetrahedron 2011, 67, 803-823

27) Multigram synthesis of trans-2-(trifluoromethyl)-cyclopropanamine
A. V. Bezdudny, D. Klukovsky, P. K. Mykhailiuk,* O. V. Shishkin, Y. M. Pustovit
Synthesis 2011, 1, 119-122

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