2025
174) A New Reagent to Access Methyl Sulfones
Y. Poplavskyi, V. Ripenko, S. Bova, A. Biitseva, Y. V. Dmitriv, A. A. Tolmachev, I. V. Sadkova, I. Pishel, O. Grygorov, V. Q. H. Phan, H. V. R. Dias,* P. K. Mykhailiuk*
Nat. Commun. 2025, 16, 1132
173) Saturated F2-Rings from Alkenes
Y. Li, X.-B. Liu, V. Sham, I. Logvinenko, J.-H. Xue, J.-Y. Wu, J.-L. Fu, S. Lin, Y. Liu, Q. Li,* P. K. Mykhailiuk,* H. Wang*
Angew. Chem. Int. Ed. 2025, 64, e202422899
172) “Angular” spirocyclic azetidines: synthesis, characterization, and evaluation in drug discovery
A. A. Kirichok, H. Tkachuk, K. Levchenko, D. Granat, T. Yegorova, D. Lesyk, A. Anisiforova, Y. Holota, V. Zomchak, I. Bodenchuk, V. Kosach, P. Borysko, R. A. Korzh, G. Al-Maali, V. Kubyshkin, H. S. Rzepa, P. K. Mykhailiuk*
Angew. Chem. Int. Ed. 2025, 64, e202418850
2024
171) Light-enabled scalable synthesis of bicyclo[1.1.1]pentane halides and their functionalizations
V. Ripenko, V. Sham, V. Levchenko, S. Holovchuk, D. Vysochyn, I. Klymov, D. Kyslyi, S. Veselovych, S. Zhersh, Y. Dmytriv, A. Tolmachev, I. Sadkova, I. Pishel, K. Horbatok, V. Kosach, Y. Nikandrova, P. K. Mykhailiuk*
Nat. Synth. 2024, 3, 1538–1549
![Light-enabled scalable synthesis of bicyclo[1.1.1]pentane halides and their functionalizations](https://mykhailiukchem.org/wp-content/uploads/2024/11/171.png)
170) CF3-Cyclobutanes: Synthesis, Properties, and Evaluation as a Unique tert-Butyl Group Analogue
V. Ahunovych, A. A. Klipkov, M. Bugera, K. Tarasenko, S. Trofymchuk, B. Razhyk, A. Boretskyi, O. Stanko, Y. Panasiuk, O. Shablykin, G. Al-Maali, D. Lesyk, O. Klymenko-Ulianov, K. Horbatok, I. Bodenchuk, V. Kosach, P. Borysko, V. Kubyshkin, P. K. Mykhailiuk*
JACS Au 2024, 4, 4507–4517
169) Proline Analogues in Drug Design: Current Trends and Future Prospects
V. Kubyshkin,* P. K. Mykhailiuk*
J. Med. Chem. 2024, 67, 20022–20055
168) Strain-Release-Driven Modular Synthesis of Oxetane-Based Amide Bioisosteres: Concise, Robust and Scalable Approach
P. Spránitz, P. Sőregi, K. Hegedüs, B. Igriczi, G. Szakács, K. Jemnitz, P. Szabó, Y. Galushchak, P. K. Mykhailiuk, T. Soós*
Angew. Chem. Int. Ed. 2024, 63, e202410554
167) Functionalization of Alkenes with Difluoromethyl Nitrile Oxide to Access the Difluoromethylated Derivatives
B. A. Chalyk, O. Zginnyk, A. V. Khutorianskyi, P. K. Mykhailiuk*
Org. Lett. 2024, 26, 2888–2892
166) Modular synthesis of cyclic β-difluoroamines
N. G. Charlesworth, D. Arunprasath, M. A. Graham, S. P. Argent, O. P. Datsenko, P. K. Mykhailiuk, R. M. Denton*
Chem. Commun. 2024, 60, 7701-7704
165) Bicyclo[m.n.k]alkane Building Blocks as Promising Benzene and Cycloalkane Isosteres: Multigram Synthesis, Physicochemical and Structural Characterization
V. V. Semeno, V. O. Vasylchenko, I. M. Fesun, L. Y. Ruzhylo, M. O. Kipriianov, K. P. Melnykov, A. Skreminskyi, R. Iminov, P. Mykhailiuk, B. V. Vashchenko, O. O. Grygorenko*
Chem. Eur. J. 2024, 24, e202303859
![Bicyclo[m.n.k]alkane Building Blocks as Promising Benzene and Cycloalkane Isosteres: Multigram Synthesis, Physicochemical and Structural Characterization](https://mykhailiukchem.org/wp-content/uploads/2024/11/165.png)
164) 2-Oxabicyclo[2.1.1]hexanes: synthesis, properties and validation as bioisosteres of ortho- and meta-Benzenes
V. V. Levterov, Y. Panasiuk, O. Shablykin, O. Stashkevych, K. Sahun, A. Rassokhin, I. Sadkova, D. Lesyk, A. Anisiforova, Y. Holota, P. Borysko, I. Bodenchuk, N. M. Voloshchuk, P. K. Mykhailiuk*
Angew. Chem. Int. Ed. 2024, 63, e202319831
![2-Oxabicyclo[2.1.1]hexanes: synthesis, properties and validation as bioisosteres of ortho- and meta-Benzenes](https://mykhailiukchem.org/wp-content/uploads/2024/02/164.png)
163) Photosensitization Enables Pauson-Khand-type Reactions with Nitrenes
F. Li, W. F. Zhu, C. Empel, O. Datsenko, A. Kumar, Y. Xu, J. H. M. Ehrler, I. Atodiresei, S. Knapp, P. K. Mykhailiuk, E. Proschak, R. M. Koenigs*
Science 2024, 383, 498
162) Spiro[3.3]heptane as a Saturated Benzene Bioisostere
K. Prysiazhniuk, O. P. Datsenko, O. Polishchuk, S. Shulha, O. Shablykin, Y. Nikandrova, K. Horbatok, I. Bodenchuk, P. Borysko, D. Shepilov, I. Pishel, V. Kubyshkin, P. K. Mykhailiuk*
Angew. Chem. Int. Ed. 2024, 63, e202316557
![Spiro[3.3]heptane as a Saturated Benzene Bioisostere](https://mykhailiukchem.org/wp-content/uploads/2024/02/162.png)
161) Nickel-Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers
G. Laudadio, P. Neigenfind, Á. Péter, C. Z. Rubel, M. A. Emmanuel, M. S. Oderinde, T. El-Hayek Ewing, M. D. Palkowitz, J. L. Sloane, K. W. Gillman, D. Ridge, M. D. Mandler, P. N. Bolduc, M. C. Nicastri, B. Zhang, S. Clementson, N. N. Petersen, P. Martín-Gago, P. Mykhailiuk, K. M. Engle,* P. S. Baran*
Angew. Chem. Int. Ed. 2024, 63, e202314617
160) Borylated cyclobutanes via thermal [2 + 2]-cycloaddition
K. Prysiazhniuk, O. Polishchuk, S. Shulha, K. Gudzikevych, O. P. Datsenko, V. Kubyshkin, P. K. Mykhailiuk*
Chem. Sci. 2024, 15, 3249-3254
![Borylated cyclobutanes via thermal [2 + 2]-cycloaddition](https://mykhailiukchem.org/wp-content/uploads/2024/02/160.png)
159) In situ studies of reversible solid–gas reactions of ethylene responsive silver pyrazolates
H. V. R. Dias, D. Parasar, A. A. Yakovenko, P. W. Stephens, Á. Muñoz-Castro, M. Vanga, P. Mykhailiuk, E. Slobodyanyuk
Chem. Sci. 2024, 15, 2019-2025
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