2018-2017

2018

114) Saturated heterocyclic aminosulfonyl fluorides ‐ novel scaffolds for protecting‐group free synthesis of sulfonamides
S. Zhersh, O. Blahun, I. Sadkova, A. Tolmachev, Y. Moroz, P. Mykhailiuk*
Chem. Eur. J. 2018, 24, 8343-8349
Saturated heterocyclic aminosulfonyl fluorides ‐ novel scaffolds for protecting‐group free synthesis of sulfonamides

113) Synthesis of Bi‐ and Polyfunctional Isoxazoles from Amino Acid‐Derived Halogenoximes and Active Methylene Nitriles
B. Chalyk, K. Hrebeniuk, K. Gavrilenko, O. Shablykin, O. Yanshyna, D. Bash, P. Mykhailiuk, O. Liashuk, O. Grygorenko*
Eur. J. Org. Chem. 2018, 22, 2753-2761
Synthesis of Bi‐ and Polyfunctional Isoxazoles from Amino Acid‐Derived Halogenoximes and Active Methylene Nitriles

112) [2+2]-Photocycloaddition of N-benzylmaleimide to alkenes as an approach to functional 3 azabicyclo[3.2.0]heptanes
Y. Skalenko, T. Druzhenko, A. Denisenko, M. Samoilenko, O. Datsenko, S. Trofymchuk, O. Grygorenko, A. Tolmachev, P. Mykhailiuk*
J. Org. Chem. 2018, 83 (12), 6275–6289
[2+2]-Photocycloaddition of N-benzylmaleimide to alkenes as an approach to functional 3 azabicyclo[3.2.0]heptanes

111) Preparation of 5-fluoropyrazoles from pyrazoles and NFSI
V. Levchenko, Y. Dmytriv, A. Tymtsunik, K. Liubchak, A. Rudnichenko, A. Melnyk, S. Veselovych, Y. Borodulin, O. Otsalyuk, A. Tolmachev, P. Mykhailiuk*
J. Org. Chem. 2018, 83 (6), 3265–3274
Preparation of 5-fluoropyrazoles from pyrazoles and NFSI

110) Synthesis of functionalized difluorocyclopropanes: unique building blocks for drug discovery
R. Bychek, V. Levterov, I. Sadkova, A. Tolmachev, P. Mykhailiuk*
Chem. Eur. J. 2018, 24, 12291-12297 (HOT paper )
Synthesis of functionalized difluorocyclopropanes: unique building blocks for drug discovery

109) Synthesis of multifunctional spirocyclic azetidines, and their application in drug discovery
A. Kirichok, I. Shton, I. Pishel, S. Zozulya, P. Borysko, V. Kubyshkin, O. Zaporozhets, A. Tolmachev, P. Mykhailiuk*
Chem. Eur. J. 2018, 24, 5444-5449
Synthesis of multifunctional spirocyclic azetidines, and their application in drug discovery

108) Synthesis of CHF2-substituted 3-azabicyclo[3.1.0]hexanes by photochemical decomposition of CHF2-pyrazolines
Y. Zheng, X. Yu, S. Lv, P. K. Mykhailiuk, Q. Ma,a L. Hai,* Y. Wu*
RSC Adv. 2018, 8, 5114-5118
Synthesis of CHF2-substituted 3-azabicyclo[3.1.0]hexanes by photochemical decomposition of CHF2-pyrazolines

107) Photochemical Synthesis of 2-Azabicyclo[3.2.0]heptanes: Advanced Building Blocks for Drug Discovery. Synthesis of 2,3-Ethanoproline
T. Druzhenko, Y. Skalenko, M. Samoilenko, A. Denisenko, S. Zozulya, P. O. Borysko, M. I. Sokolenko, A. Tarasov, P. K. Mykhailiuk*
J. Org. Chem. 2018, 83 (3), 1394–1401
Photochemical Synthesis of 2-Azabicyclo[3.2.0]heptanes: Advanced Building Blocks for Drug Discovery. Synthesis of 2,3-Ethanoproline

2017

106) Photochemical synthesis of 3-azabicyclo[3.2.0]heptanes: advanced building blocks for drug discovery
A. Denisenko, T. Druzhenko, Y. Skalenko, M. Samoilenko, O. Grygorenko, S. Zozulya, P. K. Mykhailiuk*
J. Org. Chem. 2017, 82, 9627–9636
Photochemical synthesis of 3-azabicyclo[3.2.0]heptanes: advanced building blocks for drug discovery

105) Synthesis of spirocyclic pyrrolidines: advanced building blocks for drug discovery
B. Chalyk, M. Butko, O. Yanshyna, K. Gavrilenko, T. Druzhenko, P. K. Mykhailiuk*
Chem. Eur. J. 2017, 23, 16782–16786

104) Selective 19F-labeling of functionalized carboxylic acids with difluoromethyl diazomethane (CF2HCHN2)
P. K. Mykhailiuk,* I. Kishko,V. Kubyshkin, N. Budisa, J. Cossy
Chem. Eur. J. 2017, 23, 13279–13283

103) Heptafluoroisopropyl diazomethane (i-C3F7CHN2): in situ generation and synthesis of pyrazoles
P. K. Mykhailiuk*
Org. Biomol. Chem. 2017, 15, 7296-7301

102) Synthesis of N-nitroso CHF2-pyrazolines, and transformation into CHF2-isoxazolines and pyrazoles
P. Lebed, J. Fenneteau, Y. Wu, J. Cossy, P. K. Mykhailiuk*
Eur. J. Org. Chem. 2017, 31, 4530–4542
Synthesis of N-nitroso CHF2-pyrazolines, and transformation into CHF2-isoxazolines and pyrazoles

101) Conformational Plasticity of the Cell-Penetrating Peptide SAP as Revealed by Solid-State 19F-NMR and Circular Dichroism
S. Afonin, V. Kubyshkin, P. K. Mykhailiuk, I. V. Komarov, A. S. Ulrich
J. Phys. Chem. B. 2017, 121, 6479–6491

100) A peptidyl-prolyl model study: How does the electronic effect influence the amide bond conformation?
P. K. Mykhailiuk,* V. Kubyshkin,* T. Bach, N. Budisa
J. Org. Chem. 2017, 82, 8831-8841
A peptidyl-prolyl model study: How does the electronic effect influence the amide bond conformation?

99) Difluoromethyl nitril oxide (CF2HCNO): overseen chemical reagent
A. Khutoryanskiy, B. Chalyk, P. Borysko, A. Kondratiuk, P. Mykhailiuk*
Eur. J. Org. Chem. 2017, 27, 3935-3940
Difluoromethyl nitril oxide (CF2HCNO): overseen chemical reagent

98) 1-Substituted 2-Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery
A. Kirichok, I. Shton, M. Kliachyna, I. Pishel, P. K. Mykhailiuk*
Angew. Chem. Int. Ed. 2017, 56, 8865-8869

highlighted in SynFacts, OPRD, Organometallic Chem, ChemViews
1-Substituted 2-Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery

97) Synthesis of 6-azaspiro[4.3]alkanes: innovative scaffolds for drug discovery
B. Chalyk, A. Isakov, M. Butko, K. Hrebeniuk, O. Kucher, K. Gavrilenko, T. Druzhenko, V. Yarmolchuk, S. Zozulya, P. Mykhailiuk*
Eur. J. Org. Chem. 2017, 31, 4530-4542

highlighted in SynFacts, OPRD
Synthesis of 6-azaspiro[4.3]alkanes: innovative scaffolds for drug discovery

96) Synthesis of functionalized 4-fluoropyridazines
A. Feraldi-Xypolia, G. Fredj, G. Tran, T. Tsuchiya, J.-P. Vors, P. Mykhailiuk, D.-G. Pardo, J. Cossy
Asian J. Org. Chem. 2017, 6, 927-935
Synthesis of functionalized 4-fluoropyridazines

95) Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR
S. L. Grage. M.-A. Sani, O. Cheneval, S. T. Henriques, C. Schalck, R. Heinzmann, J. S. Mylne, P. K. Mykhailiuk, S. Afonin, I. V. Komarov, F. Separovic, D. J. Craik, A. S. Ulrich
Biophys. J. 2017, 112, 630-642

94) Synthesis of fluorinated oxazoles by oxidative cyclization of fluorinated enamides
O. S. Shishlyk, A. V. Shcherbatiuk, R. T. Iminov, A. V. Tverdokhlebov,* A. A. Tolmachev, P. K. Mykhailiuk,* A. V. Biitseva
J. Fluorine.Chem. 2017, 196, 88-97

93) Synthesis of CF2H-substituted pyrazolines by [3+2]-cycloaddition between CF2HCHN2 and electron-deficient alkenes
J. Li, X.-L. Yu, J. Cossy, S.-Y. Lv, H.-L. Zhang, F. Su, L. Hai, P. K. Mykhailiuk,* Y. Wu*
Eur. J. Org. Chem. 2017, 2, 266-270

92) Synthesis of 3-oxadiazolyl/triazolyl morpholines: novel scaffolds for drug discovery
A. D. Tereshchenko, J. S. Myronchuk, L. D. Leitchenko, A. Tolmachev, K. Liubchak,* P. Mykhailiuk*
Tetrahedron 2017, 73, 750-757

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